This laboratory-based, middle school science course covers a wide range of topics that are of interest to modern scientists. It starts by describing our current understanding of atoms, molecules, the chemicals that are necessary for life, DNA, and cells. These topics are all discussed in the context of history, explaining how specific scientific advances led to the scientific explanations that the students are being taught. This allows students to learn not only the current scientific understanding of these topics, but also how scientists reached that understanding.